TAF10 Antibody

Background:

Initiation of transcription by RNA polymerase II requiresthe activities of more than 70 polypeptides. The protein thatcoordinates these activities is transcription factor IID (TFIID),which binds to the core promoter to position the polymeraseproperly, serves as the scaffold for assembly of the remainder ofthe transcription complex, and acts as a channel for regulatorysignals. TFIID is composed of the TATA-binding protein (TBP) and agroup of evolutionarily conserved proteins known as TBP-associatedfactors or TAFs. TAFs may participate in basal transcription, serveas coactivators, function in promoter recognition or modify generaltranscription factors (GTFs) to facilitate complex assembly andtranscription initiation. This gene encodes one of the smallsubunits of TFIID that is associated with a subset of TFIIDcomplexes. Studies with human and mammalian cells have shown thatthis subunit is required for transcriptional activation by theestrogen receptor, for progression through the cell cycle, and mayalso be required for certain cellular differentiation programs.