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Western blot analysis in MDA-MB231 cell line lysates (35ug/lane).
Western blot analysis in MDA-MB231 cell line lysates (35ug/lane).

TAPBP Antibody

CATALOG NUMBER: 60-069

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This TAPBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the N-terminal region of human TAPBP.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
48 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TAPBP
Additional Names:
Tapasin, TPN, TPSN, NGS-17, TAP-associated protein, TAP-binding protein, TAPBP, NGS17, TAPA
Protein Accession Number:
O15533
Ncbi Gene Id Number:
6892
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a transmembrane glycoprotein whichmediates interaction between newly assembled majorhistocompatibility complex (MHC) class I molecules and thetransporter associated with antigen processing (TAP), which isrequired for the transport of antigenic peptides across theendoplasmic reticulum membrane. This interaction is essential foroptimal peptide loading on the MHC class I molecule. Up to fourcomplexes of MHC class I and this protein may be bound to a singleTAP molecule. This protein contains a C-terminal double-lysinemotif (KKKAE) known to maintain membrane proteins in theendoplasmic reticulum. This gene lies within the majorhistocompatibility complex on chromosome 6. Alternative splicingresults in three transcript variants encoding different isoforms.
Background Reference 1:
Jiang, Q., et al. Tumour Biol. 31(5):451-459(2010)
Background Reference 2:
Rizvi, S.M., et al. Traffic 11(3):332-347(2010)
Background Reference 3:
Praveen, P.V., et al. Eur. J. Immunol. 40(1):214-224(2010)
Background Reference 4:
Barcellos, L.F., et al. PLoS Genet.(10), E1000696 (2009) :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-069

List Size:
400 ul

List Price:

$495.00

Datasheet
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