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Western blot analysis of lysed extracts from mouse brain tissue using Tau (Phospho-Thr231).
Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer’s Disease using Tau (Phospho-Thr231).
Western blot analysis of lysed extracts from mouse brain tissue using Tau (Phospho-Thr231).

Tau (phospho Thr231) Antibody

CATALOG NUMBER: 79-151

Clonality:
Polyclonal
Tested Applications:
IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Tau (Phospho-Thr231) antibody was raised against a peptide sequence around phosphorylation site of threonine 231 (V-R-T (p) -P-P) derived from Human Tau.
Conjugate:
Unconjugated
Tested Applications:
IHC, WB
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Specificity:
This antibody detects endogenous level of Tau only when phosphorylated at threonine 231.
Predicted Molecular Weight:
48, 62, 78 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Clonality:
Polyclonal
physical-state:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
MAPT
Additional Names:
TAU, MSTD, PPND, DDPAC, MAPTL, MTBT1, MTBT2, FTDP-17, CREB2, CREBP1, MAPT, MTAPT, Neurofibrillary tangle protein, PHF-tau
Protein Accession Number:
NP_001116538.1
Protein Gi Number:
178557734
Ncbi Gene Id Number:
4137
Background:
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Background Reference 1:
Yen S. H. et. al. (1997) Neurochem. 69:1709-1719. Beausoleil S. A. et. al. (2004) Proc. Natl. Acad. Sci. U. S. A. 101:12130-12135. Wintjens R. et. al. (2001) Biol. Chem. 276:25150-25156. Babu J. R. et. al. (2005) Neurochem. 94:192-203. Goedert M., Spillantini M. G. (2000) Biochim. Biophys. Acta 1502:110-121.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-151

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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