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Western blot analysis of extracts from HepG2 cells (Lane 2), using Tau (Phospho-Thr534/217) Antibody. The lane on the left is treated with antigen-specific peptide.
Western blot analysis of extracts from HepG2 cells (Lane 2), using Tau (Phospho-Thr534/217) Antibody. The lane on the left is treated with antigen-specific peptide.

Tau (phospho Thr534/217) Antibody

CATALOG NUMBER: 79-838

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Tau (phospho Thr534/217) antibody was raised against a peptide sequence around phosphorylation site of threonine 534/217 (L-P-T (p)-P-P) derived from Human Tau.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: 1:500~1:1000
Specificity:
The antibody detects endogenous levels of Tau only when phosphorylated at threonione 534/217.
Predicted Molecular Weight:
65 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
TAU
Additional Names:
MAPT, MTBT1, PHF-tau
Protein Accession Number:
NP_058519.3
Protein Gi Number:
294862261
Ncbi Gene Id Number:
4137
Background:
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Background Reference 1:
Goedert M., Proc. Natl. Acad. Sci. U.S.A. 85:4051-4055(1988).
Background Reference 2:
Goedert M., EMBO J. 8:393-399(1989).
Background Reference 3:
Lee G., Neuron 2:1615-1624(1989).

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-838

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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