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Western blot analysis of TCCR expression in human spleen tissue lysates with TCCR antibody at 1 μg/ml.
Immunohistochemistry of TCCR in human spleen tissue with TCCR antibody at 10 μg/mL.
Immunofluorescence of TCCR in A549 cells with TCCR antibody at 20 μg/mL.
Western blot analysis of TCCR expression in human spleen tissue lysates with TCCR antibody at 1 μg/ml.
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TCCR Antibody

CATALOG NUMBER: 2481

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (87%)
Immunogen:
TCCR antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human TCCR precursor.
The immunogen is located within the first 50 amino acids of TCCR.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
TCCR antibody can be used for detection of TCCR by Western blot at 1 μg/mL. An approximately 70 kDa band can be detected. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1306 - Human Spleen Tissue Lysate
Positive Control 2:
Cat. No. 10-901 - Human Spleen Tissue Slide
Positive Control 3:
Cat. No. 17-003 - A549 Cell Slide
Predicted Molecular Weight:
70 kDa
Purification:
TCCR Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
TCCR Antibody is supplied in PBS containing ≤0.09% sodium azide.
Concentration:
1 mg/ml
Storage Conditions:
TCCR antibody can be stored at 4°C, stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
IL27RA
Additional Names:
TCCR Antibody: CRL1, TCCR, WSX1, IL27R, IL-27RA, zcytor1, CRL1, UNQ296/PRO336, Interleukin-27 receptor subunit alpha, Cytokine receptor WSX-1, IL-27 receptor subunit alpha
Protein Accession Number:
NP_004834
Protein Gi Number:
4759328
Ncbi Gene Id Number:
9466
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TCCR Antibody: Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-gamma and lymphotoxin-beta that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned. It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1. TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-gamma and Th1-dependent antibody IgG2a. TCCR is predominately expressed in thymus, spleen, lymph notes and peripheral blood leukocytes.
Background Reference 1:
Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS and de Sauvage FJ. Development of Th1-type immune responses requires the type I cytokine receptor TCCR Nature 2000;407(6806):916-920
Background Reference 2:
Sprecher,C.A., Grant,F.J., Baumgartner,J.W., Presnell,S.R., Schrader,S.K., Yamagiwa,T., Whitmore,T.E., O'Hara,P.J. and Foster,D.F. Cloning and characterization of a novel class I cytokine receptor Biochem. Biophys. Res. Commun. 1998;246(1):82-90

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

2481

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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