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Western blot analysis in K562 cell line lysates (35ug/lane).
Western blot analysis in K562 cell line lysates (35ug/lane).

TCEB2 Antibody

CATALOG NUMBER: 57-645

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This TCEB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-48 amino acids from the Central region of human TCEB2.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
13 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TCEB2
Additional Names:
Transcription elongation factor B polypeptide 2, Elongin 18 kDa subunit, Elongin-B, EloB, RNA polymerase II transcription factor SIII subunit B, SIII p18, TCEB2
Protein Accession Number:
Q15370
Protein Gi Number:
32699512
Ncbi Gene Id Number:
6923
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes the protein elongin B, which is asubunit of the transcription factor B (SIII) complex. The SIIIcomplex is composed of elongins A/A2, B and C. It activateselongation by RNA polymerase II by suppressing transient pausing ofthe polymerase at many sites within transcription units. Elongin Afunctions as the transcriptionally active component of the SIIIcomplex, whereas elongins B and C are regulatory subunits. ElonginA2 is specifically expressed in the testis, and capable of forminga stable complex with elongins B and C. The von Hippel-Lindau tumorsuppressor protein binds to elongins B and C, and thereby inhibitstranscription elongation. Two alternatively spliced transcriptvariants encoding different isoforms have been described for thisgene. Pseudogenes have been identified on chromosomes 11 and 13.
Background Reference 1:
Marcsisin, S.R., et al. J. Mol. Biol. 402(5):892-904(2010)
Background Reference 2:
Piessevaux, J., et al. J. Biol. Chem. 283(31):21334-21346(2008)
Background Reference 3:
Van Herreweghe, E., et al. EMBO J. 26(15):3570-3580(2007)
Background Reference 4:
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-645

List Size:
400 ul

List Price:

$495.00

Datasheet
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