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Western blot analysis of TCTN1 in mouse kidney tissue lysate with TCTN1 antibody at (A) 1 and (B) 2μg/mL.
Immunohistochemistry of TCTN1 in human kidney tissue with TCTN1 antibody at 5 μg/mL.
Immunofluorescence of TCTN1 in Human Kidney cells with TCTN1 antibody at 20 μg/mL.
Western blot analysis of TCTN1 in mouse kidney tissue lysate with TCTN1 antibody at (A) 1 and (B) 2μg/mL.
Trial Size

TCTN1 Antibody

CATALOG NUMBER: 5833

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
TCTN1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human TCTN1.
The immunogen is located within amino acids 30 - 80 of TCTN1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
TCTN1 antibody can be used for detection of TCTN1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1405 - Mouse Kidney Tissue Lysate
Positive Control 2:
Cat. No. 10-401 - Human Kidney Tissue Slide
Purification:
TCTN1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
TCTN1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
TCTN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TCTN1
Additional Names:
TCTN1 Antibody: TECT1, JBTS13, TECT1, UNQ9369/PRO34160, Tectonic-1
Protein Accession Number:
NP_001076007
Protein Gi Number:
130978359
Ncbi Gene Id Number:
79600
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TCTN1 Antibody: TCTN1 is the founding member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. During embryonic development, TCTN1 is expressed in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
Background Reference 1:
Reiter JF and Skarnes WC. Tectonic, a novel regulator of the Hedgehog pathwy required for both activation and inhibition. Genes Dev.2006; 20:22-7.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

5833

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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