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Western blot analysis of TCTN2 in SK-N-SH cell lysate with TCTN2 antibody at 1 μg/mL.
Western blot analysis of TCTN2 in SK-N-SH cell lysate with TCTN2 antibody at 1 μg/mL.
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TCTN2 Antibody

CATALOG NUMBER: 5835

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (75%)
Immunogen:
TCTN2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TCTN2.
The immunogen is located within amino acids 610 - 660 of TCTN2.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
TCTN2 antibody can be used for detection of TCTN2 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1220 - SK-N-SH Cell Lysate
Purification:
TCTN2 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
TCTN2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
TCTN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TCTN2
Additional Names:
TCTN2 Antibody: MKS8, TECT2, C12orf38, Tectonic-2
Protein Accession Number:
NP_079085
Protein Gi Number:
31377681
Ncbi Gene Id Number:
79867
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TCTN2 Antibody: TCTN2 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN2 is not known, it is 49% similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
Background Reference 1:
Reiter JF and Skarnes WC. Tectonic, a novel regulator of the Hedgehog pathwy required for both activation and inhibition. Genes Dev.2006; 20:22-7.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

5835

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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