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Western blot analysis in mouse stomach tissue lysates (35ug/lane).
Western blot analysis in mouse stomach tissue lysates (35ug/lane).

TDP1 Antibody

CATALOG NUMBER: 59-353

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
This TDP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-239 amino acids from the Central region of human TDP1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
68 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TDP1
Additional Names:
Tyrosyl-DNA phosphodiesterase 1, Tyr-DNA phosphodiesterase 1, 314-, TDP1
Protein Accession Number:
Q9NUW8
Protein Gi Number:
37999797
Ncbi Gene Id Number:
55775
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene is involved in repairingstalled topoisomerase I-DNA complexes by catalyzing the hydrolysisof the phosphodiester bond between the tyrosine residue oftopoisomerase I and the 3-prime phosphate of DNA. This protein mayalso remove glycolate from single-stranded DNA containing 3-primephosphoglycolate, suggesting a role in repair of free-radicalmediated DNA double-strand breaks. This gene is a member of thephospholipase D family and contains two PLD phosphodiesterasedomains. Mutations in this gene are associated with the diseasespinocerebellar ataxia with axonal neuropathy (SCAN1). Whileseveral transcript variants may exist for this gene, thefull-length natures of only two have been described to date. Thesetwo represent the major variants of this gene and encode the sameisoform.
Background Reference 1:
Dexheimer, T.S., et al. Nucleic Acids Res. 38(7):2444-2452(2010)
Background Reference 2:
Chiang, S.C., et al. Cell Cycle 9(3):588-595(2010)
Background Reference 3:
Das, B.B., et al. EMBO J. 28(23):3667-3680(2009)
Background Reference 4:
Zhou, T., et al. DNA Repair (Amst.) 8(8):901-911(2009)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-353

List Size:
400 ul

List Price:

$495.00

Datasheet
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