TFE3 Antibody

Background:

The microphthalmia transcription factor/transcriptionfactor E (MITF-TFE) family of basic helix-loop-helix leucine zipper(bHLH-Zip) transcription factors includes four family members:MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this geneactivates transcription through binding to the muE3 motif of theimmunoglobulin heavy-chain enhancer. The TFEC protein formsheterodimers with the TEF3 protein and inhibits TFE3-dependenttranscription activation. The TEF3 protein interacts withtranscription regulators such as E2F3, SMAD3, and LEF-1, and isinvolved in TGF-beta-induced transcription, playing important rolesin cell growth, proliferation, and osteoclast and macrophagedifferentiation. The TFE3 protein also activates hepatic IRS-2gene, and induces hexokinase II (HK2) and insulin-induced gene 1(INSIG1); it participates in insulin signaling and could be atherapeutic target for diabetes. This gene is also involved inchromosomal translocations, resulting in different fusion geneproducts in papillary renal cell carcinomas and alveolar soft partsarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO(p54nrb)-TFE3 and ASPL-TFE3.