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Immunohistochemistry of TFEB in human lung tissue with TFEB antibody at 2.5 μg/mL.
Immunofluorescence of TFEB in human lung tissue with TFEB antibody at 20 μg/mL.
Immunohistochemistry of TFEB in human lung tissue with TFEB antibody at 2.5 μg/mL.
Trial Size

TFEB Antibody

CATALOG NUMBER: 6803

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
Rabbit polyclonal TFEB antibody was raised against a 16 amino acid peptide near the carboxy terminus of human TFEB.
The immunogen is located within amino acids 390 - 440 of TFEB.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P
Application Note:
TFEB antibody can be used for detection of TFEB by immunohistochemistry at 2.5 μg/ml.
Antibody validated: Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity:
TFEB antibody is human specific. At least three isoforms of TFEB are known to exist.
Positive Control 1:
Cat. No. 10-101 - Human Lung Tissue Slide
Predicted Molecular Weight:
N/A
Purification:
TFEB antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
TFEB antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
TFEB antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
TFEB
Additional Names:
TFEB Antibody: TCFEB, BHLHE35, ALPHATFEB, Transcription factor EB, Class E basic helix-loop-helix protein 35, bHLHe35
Protein Accession Number:
NP_009093
Protein Gi Number:
24307933
Ncbi Gene Id Number:
7942
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The Transcription factor EB (TFEB) is a member in the basic helix-loop-helix leucine zipper superfamily of transcription factors that is translocated in a subset of renal tumors (1,2). Recent studies have shown that lysosomal biogenesis is regulated by TFEB (3), which is in turn regulated by the mammalian target of rapamycin (mTOR) complex 1 (4). Other evidence suggests that TFEB coordinates the major steps of the autophagic pathway by driving the expression of autophagy and lysosomal genes (5).
Background Reference 1:
Carr CS and Sharp PA. A helix-loop-helix protein related to the immunoglobulin E box-binding proteins. Mol. Cell Biol. 1990; 10:4384-8.
Background Reference 2:
Davis IJ, Hsi BL, Arroyo JD, et al. Cloning of an alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation. Proc. Natl. Acad. Sci. USA 2003; 100:6051-6.
Background Reference 3:
Sardiello M, Palmieri M, di Ronza A, et al. A gene network regulating lysosomal biogenesis and function. Science 2009; 325:473-7.
Background Reference 4:
Pena-Llopis S, Vega-Rubin-de-Celis S, Schwartz JC, et al. Regulation of TFEB and V-ATPases my mTORC1. EMBO J. 2011; 30:3242-58.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6803

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.

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