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TGF beta Receptor II (phospho Ser225/250) Antibody

CATALOG NUMBER: 79-819

Clonality:
Polyclonal
Tested Applications:
IHC
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
TGF beta Receptor II (phospho Ser225/250) antibody was raised against a peptide sequence around phosphorylation site of Serine 225/250 (D-R-S (p)-D-I) derived from Human TGF beta Receptor II.
Conjugate:
Unconjugated
Tested Applications:
IHC
Specificity:
The antibody detects endogenous levels of TGF beta Receptor II only when phosphorylated at serine 225/250.
Predicted Molecular Weight:
64 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
TGFBR2
Additional Names:
TGF-betaR2, TGFR2, kinase TGF-beta-R2
Protein Accession Number:
NP_003233.4
Protein Gi Number:
67782324
Ncbi Gene Id Number:
7048
Background:
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis.
Background Reference 1:
RC Tripathi, Invest. Ophthalmol. Vis. Sci., Jan 1993; 34: 260.
Background Reference 2:
N Chegini, Endocrinology, Jul 1994; 135: 439.
Background Reference 3:
GW Mulheron, Endocrinology, Dec 1992; 131: 2609

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-819

List Size:
0.1 mg

List Price:

$376.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

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