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Western blot analysis of TGM7 in human lung tissue lysate with TGM7 antibody at 1 μg/mL.
Immunocytochemistry of TGM7 in A549 cells with TGM7 antibody at 2.5 μg/mL.
Immunofluorescence of TGM7 in A549 cells with TGM7 antibody at 10 μg/mL.
Western blot analysis of TGM7 in human lung tissue lysate with TGM7 antibody at 1 μg/mL.
Trial Size

TGM7 Antibody

CATALOG NUMBER: 6541

Clonality:
Polyclonal
Tested Applications:
ELISA, ICC, IF, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
TGM7 antibody was raised against a 13 amino acid synthetic peptide near the center of human TGM7.
The immunogen is located within amino acids 460 - 510 of TGM7.
Conjugate:
Unconjugated
Tested Applications:
ELISA, ICC, IF, WB
Application Note:
TGM7 antibody can be used for detection of TGM7 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL. For immunofluorescence start at 10 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity:
TGM7 antibody is predicted to not cross-react with other TGase protein family members. At least two isoforms of TGM7 are known to exist; this antibody will recognize both isoforms.
Positive Control 1:
Cat. No. 1302 - Human Lung Tissue Lysate
Positive Control 2:
Cat. No. 17-003 - A549 Cell Slide
Purification:
TGM7 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
TGM7 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
TGM7 antibody can be stored at 4°C, stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TGM7
Additional Names:
TGM7 Antibody: TGMZ, Protein-glutamine gamma-glutamyltransferase Z, Transglutaminase Z, TGZ
Protein Accession Number:
AF363393
Protein Gi Number:
16445035
Ncbi Gene Id Number:
116179
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TGM7 Antibody: Transglutaminases (TGM) are a family of structurally and functionally related Ca2+-dependent enzymes (TGases) that stabilize protein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks. TGases influence numerous biological processes, including blood coagulation, cell differentiation, fertilization and apoptosis. TGM7 belongs to the transglutaminase superfamily and is also thought to catalyze the cross-linking of proteins, often resulting in stabilization of protein assemblies. Little is known of the role of TGM7, but defects in the highly related protein TGM5 are associated with acral peeling skin syndrome.
Background Reference 1:
Ueki S, et al. Dual functions of transglutaminase in novel cell adhesion. J. Cell Sci. 1996; 109:2727-35
Background Reference 2:
Grenard P, Bates MK, and Aeschlimann D. Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. J. Biol. Chem. 2001; 276:33066-78.
Background Reference 3:
Cassidy AJ, van Steensel MA, Steijlen PM, et al. A homozygous missense mutation in TGM7 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome. Am. J. Hum. Genet. 2005; 77:909-17.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6541

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

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