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Western blot analysis of THAP11 in human brain tissue lysate with THAP11 antibody at 1 μg/ml.
Western blot analysis of THAP11 in human brain tissue lysate with THAP11 antibody at 1 μg/ml.
Trial Size

THAP11 Antibody

CATALOG NUMBER: 7613

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen:
THAP11 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human THAP11.
The immunogen is located within the last 50 amino acids of THAP11.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
THAP11 antibody can be used for detection of THAP11 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Specificity:
THAP11 antibody is human, mouse and rat reactive.
Positive Control 1:
Cat. No. 1303 - Human Brain Tissue Lysate
Predicted Molecular Weight:
Predicted: 35 kDa
Observed: 38 kDa
Purification:
THAP11 antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
THAP11 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
THAP11 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
THAP11
Additional Names:
THAP11 Antibody: RONIN, CTG-B43a, CTG-B45d, HRIHFB2206, THAP domain-containing protein 11
Protein Accession Number:
NP_065190
Protein Gi Number:
40354197
Ncbi Gene Id Number:
57215
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The THAP domain-contining protein 11 (THAP11), also known as Ronin, is an essential factor involved in embryonic stem (ES) cell pluripotency and cell growth (1). THAP 11 contains a THAP domain, a conserved DNA-binding domain common to many proteins associated with chromatin modification and gene expression silencing, and has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases (2). THAP11 can also negatively regulate CD44 v6 expression through its interaction with the poly(rC) binding protein PCBP1 (3).
Background Reference 1:
Dejosez M, Krumenacker JS, Zitur LJ, et al. Ronin is essential for embryogenesis and the pluripotency of mouse ES cells. Cell 2008; 133:1162-74.
Background Reference 2:
Roussigne M, Kossida S, Lavigne AC, et al. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. Trends Biochem. Sci. 2003; 28:66-9.
Background Reference 3:
Lian WX, Yin RH, Kong XZ, et al. THAP11, a novel binding protein of PCBP1, negatively regulates CD44 alternative splicing and cell invasion in a human hepatoma cell line. FEBS Lett. 2012; 586:1431-8.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7613

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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