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Western blot of hippocampal lysate showing specific immunolabeling of the ~58k TR-alpha2 protein.
Western blot of hippocampal lysate showing specific immunolabeling of the ~58k TR-alpha2 protein.

Thyroid Hormone Receptor Antibody [1330]

CATALOG NUMBER: 50-172

Clonality:
Monoclonal
Tested Applications:
WB
Host Species:
Mouse
Species Reactivity:
Bovine, Dog, Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
Bovine, Dog, Human, Mouse, Rat
Immunogen:
Peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, a2-isotype.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
The antibody has been directly tested for reactivity in Western blots with human tissue. It is anticipated that the antibody will react with bovine, canine, mouse and rat based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Predicted Molecular Weight:
58
Purification:
Protein G purified
Clonality:
Monoclonal
Isotype:
IgG1
physical-state:
Liquid
Concentration:
batch dependent
Storage Conditions:
Thyroid Hormone Receptor antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
Ncbi Official Symbol:
THRA
Protein Accession Number:
P10827
Protein Gi Number:
135705
Ncbi Gene Id Number:
7067
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors, TRalpha1, TRalpha2, TRbeta1 and TRbeta2. TRalpha1, TRbeta1 and TRbeta2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).
Background Reference 1:
Ambrogini P, Cuppini R, Ferri P, Mancini C, Ciaroni S, Voci A, Gerdoni E, Gallo G (2005) Thyroid hormones affect neurogenesis in the dentate gyrus of adult rat. Neuroendocrinology 81:244-253.
Background Reference 2:
Chan S, Kilby MD (2000) Thyroid hormone and central nervous system development. J Endocrinol 165:1-8.
Background Reference 3:
Constantinou C, Margarity M, Valcana T (2005) Region-specific effects of hypothyroidism on the relative expression of thyroid hormone receptors in adult rat brain. Mol Cell Biochem 278:93-100.

FOR RESEARCH USE ONLY

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Disclaimer:
This product is for research use only.

CATALOG NUMBER:

50-172

List Size:
0.1 mL

List Price:

$540.00

Datasheet
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