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Human TIGIT, Mouse IgG2a Fc tag, low endotoxin on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Human TIGIT, Mouse IgG2a Fc tag, low endotoxin on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

TIGIT Recombinant Protein

CATALOG NUMBER: 96-955

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Met 22 - Pro 141
Fusion Tag:
mouse IgG2a Fc tag
Tested Applications:
ELISA, WB
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Predicted Molecular Weight:
40.1 kDa
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human CD155, Fc Tag at 5 ug/mL (100 uL/well) can bind Human TIGIT, mouse IgG2a Fc tag with a linear range of 3.9-62.5 ng/mL.
Purity:
>95% as determined by SDS-PAGE.

Endotoxin level is less than 0.1 EU per ug by the LAL method.
physical-state:
Lyophilized
Buffer:
Tris with Glycine, Arginine and NaCl, pH7.5
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
TIGIT
Additional Names:
TIGIT,VSIG9,VSTM3
Protein Accession Number:
AAI01290
Ncbi Gene Id Number:
201633
Background:
TIGIT (also called T cell immunoreceptor with Ig and ITIM domains) is one newly discovered immune receptor on some percentage of T cells and Natural Killer Cells(NK). It is also identified as WUCAM and Vstm3. TIGIT could bind to CD155(PVR) on dendritic cells(DCs), macrophages, etc. with high affinity, and also to CD112(PVRL2) with lower affinity. TIGIT expressing CD8+ T cells has been shown to be expanded and associated with clinical markers of HIV disease progression in a diverse group of HIV infected individuals. TIGIT and PD-1 has been shown to be over expressed on tumor antigen-sepcific (TA-specific) CD8+ T cells and CD8+ tumor infiltrating lymphocytes (TILs) from individuals with melanoma. Blockade of TIGIT and PD-1 led to increased cell proliferation, cytokine production, and degranulation of TA-specific CD8+ T cells and TIL CD8+ T cells.
Background Reference 1:
Chew GM., et al., 2016, PLoS Pathogens., 12: e1005349.
Background Reference 2:
Joe-Marc Chauvin, et al., 2015, J Clin Invest., 125 (5): 2046-2058.
Background Reference 3:
Steven G. Deeks, 2012, Nature, 487 (1): 439-440.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-955

List Size:
0.1 mg

List Price:

$577.00

Datasheet
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