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Western blot analysis of TL1A in PC-3 cell lysates with TL1A antibody at (A) 0.5, (B) 1, and (C) 2 μg/mL.
Western blot analysis of TL1A in PC-3 cell lysates with TL1A antibody at (A) 0.5, (B) 1, and (C) 2 μg/mL.
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TL1A Antibody

CATALOG NUMBER: 3109

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
TL1A antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human TL1A.
The immunogen is located within amino acids 60 - 110 of TL1A.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
TL1A antibody can be used for detection of TL1A by Western blot at 0.5 to 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Specificity:
This polyclonal antibody will not cross-react with TL1.
Positive Control 1:
Cat. No. 1216 - PC-3 Cell Lysate
Predicted Molecular Weight:
Predicted: 28 kDa
Observed: 26 kDa
Purification:
TL1A Antibody is DEAE purified.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
TL1A Antibody is supplied in PBS containing ≤0.09% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
TL1A antibody can be stored at 4°C, stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TNFSF15
Additional Names:
TL1A Antibody: TL1, TL1A, VEGI, VEGI192A, TL1, Tumor necrosis factor ligand superfamily member 15, TNF ligand-related molecule 1
Protein Accession Number:
AAM77366
Protein Gi Number:
21745392
Ncbi Gene Id Number:
9966
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TL1A Antibody: Members in the TNF and its receptor superfamilies regulate immune responses and induce apoptosis. DR3 (also termed Wsl-1, Apo-3, TRAMP, and LARD) is preferentially expressed by T lymphocytes and upregulated during T cell activation. The ligand for DR3 was recently identified and designated TL1A. TL1A also binds decoy receptor DcR3/TR6, which is expressed in several lung and colon carcinomas and in some normal tissues. TL1A induces apoptosis and NF-κB activation in DR3 expressing cells, which is antagonized by DcR3. TL1A is upregulated by proinflammatory cytokines TNF and IL-1. TL1A is a longer variant of TL1 (also called VEGI).
Background Reference 1:
Chinnayan AM, O'Rourke K, Yu GL, et al. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 1996; 274:990-2.
Background Reference 2:
Kitson J, Raven T, Jiang YP, et al. A death-domain-containing receptor that mediates apoptosis. Nature 1996; 384:372-5.
Background Reference 3:
Screaton GR, Xu XN, Olsen AL, et al. LARD: a new lymphoid-specific death domain containing receptor regulated by pre-mRNA splicing. Proc. Natl. Acad. Sci. USA 1997; 94:4615-9.
Background Reference 4:
Bodmer JL, Burns K, Schneider P. TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas (Apo-1/CD95). Immunity 1997; 6:79-88.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

3109

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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