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Western blot analysis of TL1A in human placenta tissue lysate with TL1A antibody at 2 μg/mL.
Western blot analysis of TL1A in human placenta tissue lysate with TL1A antibody at 2 μg/mL.
Trial Size

TL1A Antibody

CATALOG NUMBER: 3789

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
TL1A antibody was raised against recombinant human TL1A.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
TL1A antibody can be used for detection of TL1A by Western blot at 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Specificity:
TL1A will not cross-react with TL1.
Positive Control 1:
Cat. No. 1309 - Human Placenta Tissue Lysate
Predicted Molecular Weight:
Predicted: 28 kDa
Observed: 30 kDa
Purification:
TL1A Antibody is Protein A purified.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
TL1A Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
TL1A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TNFSF15
Additional Names:
TL1A Antibody: TL1, TL1A, VEGI, VEGI192A, TL1, Tumor necrosis factor ligand superfamily member 15, TNF ligand-related molecule 1
Protein Accession Number:
AAM77366
Protein Gi Number:
21745392
Ncbi Gene Id Number:
9966
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TL1A Antibody: Members in the TNF and its receptor superfamilies regulate immune responses and induce apoptosis. DR3 (also termed Wsl-1, Apo-3, TRAMP, and LARD) is preferentially expressed by T lymphocytes and upregulated during T cell activation. The ligand for DR3 was recently identified and designated TL1A. TL1A also binds decoy receptor DcR3/TR6, which is expressed in several lung and colon carcinomas and in some normal tissues. TL1A induces apoptosis and NF-κB activation in DR3 expressing cells, which is antagonized by DcR3. TL1A is upregulated by proinflammatory cytokines TNF and IL-1. TL1A is a longer variant of TL1 (also called VEGI).
Background Reference 1:
Chinnayan AM, O'Rourke K, Yu GL, et al. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 1996; 274:990-2.
Background Reference 2:
Kitson J, Raven T, Jiang YP, et al. A death-domain-containing receptor that mediates apoptosis. Nature 1996; 384:372-5.
Background Reference 3:
Screaton GR, Xu XN, Olsen AL, et al. LARD: a new lymphoid-specific death domain containing receptor regulated by pre-mRNA splicing. Proc. Natl. Acad. Sci. USA 1997; 94:4615-9.
Background Reference 4:
Bodmer JL, Burns K, Schneider P. TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas (Apo-1/CD95). Immunity 1997; 6:79-88.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

3789

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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