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Western blot analysis of TMEM106B in human brain tissue lysate with TMEM106B antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry of TMEM106B in human liver tissue with TMEM106B antibody at 2.5 μg/mL.
Immunofluorescence of TMEM106B in human liver tissue with TMEM106A antibody at 20 μg/mL.
Western blot analysis of TMEM106B in human brain tissue lysate with TMEM106B antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Trial Size

TMEM106B Antibody

CATALOG NUMBER: 6783

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (100%), Bovine: (87%), Rat: (86%)
Immunogen:
TMEM106B antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human TMEM106B.
The immunogen is located within the first 50 amino acids of TMEM106B.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
TMEM106B antibody can be used for detection of TMEM106B by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 2.5 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity:
This TMEM106B antibody is predicted to have no cross-reactivity to TMEM106A.
Positive Control 1:
Cat. No. 1303 - Human Brain Tissue Lysate
Positive Control 2:
Cat. No. 10-201 - Human Liver Tissue Slide
Predicted Molecular Weight:
Predicted: 30 kDa
Observed: 33 kDa
Purification:
TMEM106B Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
TMEM106B Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
TMEM106B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TMEM106B
Additional Names:
TMEM106B Antibody: Transmembrane protein 106B
Protein Accession Number:
NP_060844
Protein Gi Number:
40254893
Ncbi Gene Id Number:
54664
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TMEM106B Antibody: Transmembrane protein 106B (TMEM106B) is a single-pass transmembrane protein that is thought to be a novel risk factor for frontotemporal lobar degeneration (FTLD), a group of clinically, pathologically and genetically heterogeneous disorders associated with atrophy in the frontal lobe and temporal lobe of the brain. The actual role of TMEM106B, and that of the closely related protein TMEM106A are still undetermined.
Background Reference 1:
Van Deerlin VM, Sleiman PM, Martinez-Lage M, et al. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat. Genet. 2010; 42:234-9.
Background Reference 2:
Aswathy PM, Jairani PS, and Mathuranath PS. Genetics of frontotemporal lobar degeneration. Ann. Indian Acad. Neurol. 2010; 13(Suppl 2):S55-62.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6783

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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