TMEM173 Antibody

CATALOG NUMBER: 26-276

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TMEM173.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
TMEM173 antibody can be used for detection of TMEM173 by ELISA at 1:62500. TMEM173 antibody can be used for detection of TMEM173 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Positive Control 1:
Cat. No. 1201 - HeLa Cell Lysate
Predicted Molecular Weight:
42 kDa
Purification:
Antibody is purified by peptide affinity chromatography method.
Clonality:
Polyclonal
Physical State:
Liquid
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Storage Conditions:
For short periods of storage (days) store at 4°C. For longer periods of storage, store TMEM173 antibody at -20°C. As with any antibody avoid repeat freeze-thaw cycles.
Ncbi Official Symbol:
TMEM173
Additional Names:
TMEM173, FLJ38577, ERIS, MITA, MPYS, NET23, STING
Protein Accession Number:
NP_938023
Protein Gi Number:
38093659
Ncbi Gene Id Number:
340061
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TMEM173 acts as a facilitator of innate immune signaling. It is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. TMEM173 may be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons.It also may be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). TMEM173 mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
Background Reference 1:
Gerhard, D.S., Genome Res. 14 (10B), 2121-2127 (2004).

FOR RESEARCH USE ONLY

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Disclaimer:
This product is for research use only.

CATALOG NUMBER:

26-276

List Size:
100 ul

List Price:

$519.00

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