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Western blot analysis in MDA-MB231 cell line lysates (35ug/lane).
TMEM43 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human esophageal carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in MDA-MB231 cell line lysates (35ug/lane).

TMEM43 Antibody

CATALOG NUMBER: 56-541

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This TMEM43 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the Central region of human TMEM43.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
45 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TMEM43
Additional Names:
Transmembrane protein 43, Protein LUMA, TMEM43
Protein Accession Number:
Q9BTV4
Protein Gi Number:
74733151
Ncbi Gene Id Number:
79188
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene belongs to the TMEM43 family. Defects in thisgene are the cause of familial arrhythmogenic right ventriculardysplasia type 5 (ARVD5), also known as arrhythmogenic rightventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic rightventricular dysplasia is an inherited disorder, often involvingboth ventricles, and is characterized by ventricular tachycardia,heart failure, sudden cardiac death, and fibrofatty replacement ofcardiomyocytes. This gene contains a response element for PPARgamma (an adipogenic transcription factor), which may explain thefibrofatty replacement of the myocardium, a characteristicpathological finding in ARVC.
Background Reference 1:
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 2:
Barahona-Dussault, C., et al. Clin. Genet. 77(1):37-48(2010)
Background Reference 3:
Hodgkinson, K., et al. Genet. Med. 11(12):859-865(2009)
Background Reference 4:
Merner, N.D., et al. Am. J. Hum. Genet. 82(4):809-821(2008)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

56-541

List Size:
400 ul

List Price:

$495.00

Datasheet
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