Tofacitinib . citrate

CATALOG NUMBER: 10-047

Specifications

Predicted Molecular Weight:

312.4 . 192.1

Formula:

C16H20N6O . C6H8O7

Cas:

540737-29-9

Solubility:

Soluble in ethanol (10mg/ml), DMSO (15mg/ml) or DMF (20mg/ml).

Inchi Key:

SYIKUFDOYJFGBQ-YLAFAASESA-N

Smiles:

OC(CC(O)=O)(CC(O)=O)C(O)=O.O=C(CC#N)N1C[C@@H]([C@H](C)CC1)N(C)C2=NC=NC3=C2C=CN3

Identity:

Determined by 1H-NMR.

Advanced Validation

Properties

Purity:

greater than or equal to 98% (HPLC)

physical-state:

Lyophilized

Storage Conditions:

Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Protect from moisture and oxygen. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.

Additional Info

Additional Names:

CP-690550; Xeljanz; Tasocitinib

Background

Background:

Potent cell permeable JAK3 inhibitor (IC50 = 1nM). Shows also JAK-1 inhibitory activity. Immunosuppressive and anti-inflammatory agent. Inhibits signaling through heterodimeric receptors associated with JAK3, JAK1, or both of them, with functional selectivity over JAK2-paired receptors. Blocks downstream STAT signaling, resulting in potent inhibition of several cytokines, including interleukins 2, 4, 7, 9, 15 and 21, which are integral to lymphocyte activation, function and proliferation. Investigated for several autoimmune disorders including, rheumatoid arthritis and psoriasis. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro. It is investigated against the spread of the SARS-CoV-2 (COVID-19). PRK1 inhibitor.

Citations

Set Contents

Disclaimer

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:

This product is for research use only.

CATALOG NUMBER:

10-047

List Size:

100 mg

List Price:

$318.00

Datasheet

Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

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