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Western blot analysis in mouse bladder tissue lysates (35ug/lane).
Western blot analysis in mouse bladder tissue lysates (35ug/lane).

TOP3B Antibody

CATALOG NUMBER: 58-713

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
This TOP3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 826-854 amino acids from the C-terminal region of human TOP3B.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
97 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TOP3B
Additional Names:
DNA topoisomerase 3-beta-1, DNA topoisomerase III beta-1, TOP3B, TOP3B1
Protein Accession Number:
O95985
Ncbi Gene Id Number:
8940
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a DNA topoisomerase, an enzyme thatcontrols and alters the topologic states of DNA duringtranscription. This enzyme catalyzes the transient breaking andrejoining of a single strand of DNA which allows the strands topass through one another, thus relaxing the supercoils and alteringthe topology of DNA. The enzyme interacts with DNA helicase SGS1and plays a role in DNA recombination, cellular aging andmaintenance of genome stability. Alternative splicing of theC-terminus of this gene results in three transcript variants whichhave distinct tissue specificity; however, not all variants havebeen fully described.
Background Reference 1:
Oliveira-Costa, J.P., et al. Hum. Pathol. 41(11):1624-1630(2010)
Background Reference 2:
Lesch, K.P., et al.Neural Transm 115(11):1573-1585(2008)
Background Reference 3:
Cho, Y.H., et al. Biochim. Biophys. Acta 1679(3):272-278(2004)
Background Reference 4:
Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-713

List Size:
400 ul

List Price:

$495.00

Datasheet
Shipping Info

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