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TOR Signaling Pathway Detection Set

CATALOG NUMBER: PSI-1805

Clonality:
Polyclonal
Tested Applications:
IF, IHC, WB
Species Reactivity:
Human
Specifications
Species Reactivity:
Human
Immunogen:
Rabbit polyclonal antibodies were raised against peptides corresponding to amino acid sequences from each of the corresponding proteins.
Tested Applications:
IF, IHC, WB
Set Contents:
TOR Antibody (NT), Cat. No. 3485 (50 μg)

Raptor Antibody (IN), Cat. No. 3493 (50 μg)

GΒL Antibody (CT), Cat. No. 3495 (50 μg)

Rheb Antibody (IN), Cat. No. 3501 (50 μg)

TSC1 Antibody (CT), Cat. No. 3503 (50 μg)

TSC2 Antibody (CT), Cat. No. 3507 (50 μg)

4E-BP1 Antibody, Cat. No. 3513 (50 μg)

Akt1 Antibody, Cat. No. 3519 (50 μg)
Purification:
Antibodies are supplied as affinity chromatography purified IgG.
Clonality:
Polyclonal
physical-state:
Liquid
Buffer:
PBS containing 0.02% sodium azide.
Concentration:
Antibody 1 mg/mL
Storage Conditions:
Stable at 4°C for three months, store at -20°C for up to one year.
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The mammalian Target of Rapamycin (TOR, also known as mTOR) is an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle progression through its ability to integrate signals from nutrient levels and growth factors. TOR regulation is accomplished through a network of various activators and repressors. It is phosphorylated by Akt, whose activity is indirectly inhibited by the lipid phosphatase PTEN. TOR is normally associated with the regulatory proteins RAPTOR, a scaffold protein whose binding by TOR substrates is necessary for effective TOR-catalyzed phosphorylation, and GΒL, which stimulates TOR’s kinase activity towards downstream proteins. It is further regulated by the proteins Rheb, TSC1 and TSC2, which act to modulate TOR activity. The downstream targets of TOR are thought to be the ribosomal protein S6 kinases and the eukaryotic initiation factor 4E binding proteins (4EBPs) whose activation leads to increased protein translation and cell growth.

For images please see PDF data sheet
Background Reference 1:
Shamji AF, Ngheim P, and Schreiber SL. Integration of growth factor and nutrient signaling: implications for cancer biology. Mol. Cell 2003; 12:271-80.
Background Reference 2:
Nave BT, Ouwens M, Withers DJ, et al. Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem. J. 1999; 344:427-31.
Background Reference 3:
Yonezawa K, Tokunaga C, Oshiro N, et al. Raptor, a binding partner of target of rapamycin. Biochem. Biophys. Res. Commun. 24; 313:437-441.
Background Reference 4:
Fingar DC and Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004; 23:3151-71.
Set Contents:
TOR Antibody (NT), Cat. No. 3485 (50 μg)

Raptor Antibody (IN), Cat. No. 3493 (50 μg)

GΒL Antibody (CT), Cat. No. 3495 (50 μg)

Rheb Antibody (IN), Cat. No. 3501 (50 μg)

TSC1 Antibody (CT), Cat. No. 3503 (50 μg)

TSC2 Antibody (CT), Cat. No. 3507 (50 μg)

4E-BP1 Antibody, Cat. No. 3513 (50 μg)

Akt1 Antibody, Cat. No. 3519 (50 μg)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

PSI-1805

List Size:
1 Set

List Price:

$1,349.00

Out of stock

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.

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