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Western blot analysis of TP1 in human kidney tissue lysate with TP1 antibody at (A) 0.5 and (B) 1 μg/mL.
Immunohistochemical staining of human lung tissue using TP1 antibody at 2.5 μg/mL.
Immunofluorescence of TP-1 in Human Lung cells with TP-1 antibody at 20 μg/mL.
Western blot analysis of TP1 in human kidney tissue lysate with TP1 antibody at (A) 0.5 and (B) 1 μg/mL.
Trial Size

TP1 Antibody

CATALOG NUMBER: 2345

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
TP1 antibody was raised against a 20 amino acid synthetic peptide from near the amino terminus of human TP1.
The immunogen is located within the first 50 amino acids of TP1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
TP1 antibody can be used for detection of TP1 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1305 - Human Kidney Tissue Lysate
Positive Control 2:
Cat. No. 10-101 - Human Lung Tissue Slide
Predicted Molecular Weight:
Predicted: 290 kDa
Observed: 290 kDa
Purification:
TP1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
TP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/ml
Storage Conditions:
TP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TEP1
Additional Names:
TP1 Antibody: TP1, TLP1, p240, TROVE1, VAULT2, TP1, Telomerase protein component 1, Telomerase-associated protein 1, Telomerase protein 1
Protein Accession Number:
AAC51107
Protein Gi Number:
1848277
Ncbi Gene Id Number:
7011
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TP1 Antibody: Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.
Background Reference 1:
Greider CW. Telomere length regulation. Annu. Rev. Biochem.1996; 274:92-7.
Background Reference 2:
Cong YS, Wright WE, and Shay JW. Human telomerase and its regulation. Microbiol. Mol. Biol. Rev.2002; 66:407-25.
Background Reference 3:
Harrington L, McPhail T, Mar V, et al. A mammalian telomerase-associated protein. Science1997; 275:973-7.
Background Reference 4:
Wong JMY and Collins K. Telomere maintenance and disease. Lancet2003; 362:983-8.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

2345

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

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