TP63 Antibody

Background:

This gene encodes a member of the p53 family oftranscription factors. An animal model, p63 -/- mice, has beenuseful in defining the role this protein plays in the developmentand maintenance of stratified epithelial tissues. p63 -/- mice haveseveral developmental defects which include the lack of limbs andother tissues, such as teeth and mammary glands, which develop as aresult of interactions between mesenchyme and epithelium. Mutationsin this gene are associated with ectodermal dysplasia, and cleftlip/palate syndrome 3 (EEC3); split-hand/foot malformation 4(SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULTsyndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammarysyndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Bothalternative splicing and the use of alternative promoters resultsin multiple transcript variants encoding different proteins. Manytranscripts encoding different proteins have been reported but thebiological validity and the full-length nature of these variantshave not been determined.