TPO Recombinant Protein

CATALOG NUMBER: 40-585

Specifications
source-species:
E. coli
Species:
Rat
source-species:
E. coli
Recombinant Protein Sequence:
SPVPPACDPR LLNKLLRDSY LLHSRLSQCP DVNPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPPQGRTTA HKDPSALFLS LQQLLRGKVR FLLLVEGPAL CVRRTLPTTA VPSRTSQLLT LNKF
Biological Activity:
Biological activity was determined by its ability to stimulate the proliferation of human MO7e cells. The expected B>ED50 is ≤ 0.2 ng/mL, corresponding to a specific activity of ≥ 5 x 106 units/mg. Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
physical-state:
Lyophilized
Storage Conditions:
The lyophilized TPO recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted TPO stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing TPO recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Ncbi Official Symbol:
Thpo
Additional Names:
Thrombopoietin
Protein Accession Number:
NP_112395.1
Protein Gi Number:
13592113
Ncbi Gene Id Number:
81811
Background:
TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant rat TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein.

FOR RESEARCH USE ONLY

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Disclaimer:
This product is for research use only.

CATALOG NUMBER:

40-585

List Size:
0.002 mg, 0.01 mg

List Price:

Price range: $199.00 through $305.00

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