TPSD1 Antibody

Background:

Tryptases comprise a family of trypsin-like serineproteases, the peptidase family S1. Tryptases are enzymaticallyactive only as heparin-stabilized tetramers, and they are resistantto all known endogenous proteinase inhibitors. Several tryptasegenes are clustered on chromosome 16p13.3. These genes arecharacterized by several distinct features. They have a highlyconserved 3' UTR and contain tandem repeat sequences at the 5'flank and 3' UTR which are thought to play a role in regulation ofthe mRNA stability. Although this gene may be an exception, most ofthe tryptase genes have an intron immediately upstream of theinitiator Met codon, which separates the site of transcriptioninitiation from protein coding sequence. This feature ischaracteristic of tryptases but is unusual in other genes.Tryptases have been implicated as mediators in the pathogenesis ofasthma and other allergic and inflammatory disorders. TPSD1 wasonce considered to be a pseudogene, although it is now believed tobe a functional gene that encodes a protein.