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Western blot analysis of TPT1 in human brain tissue lysate with TPT1 antibody at (A) 0.5 and (B) 1 μg/mL.
Immunohistochemistry of TPT1 in rat brain tissue with TPT1 antibody at 2.5 μg/ml.
Immunofluorescence of TPT1 in rat brain tissue with TPT1 antibody at 20 μg/ml.
Western blot analysis of TPT1 in human brain tissue lysate with TPT1 antibody at (A) 0.5 and (B) 1 μg/mL.
Trial Size

TPT1 Antibody

CATALOG NUMBER: 7193

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Rabbit: (100%), Bovine: (100%), Pig: (100%), Chicken: (74%)
Immunogen:
Rabbit polyclonal TPT1 antibody was raised against a 19 amino acid peptide near the center of human TPT1.
The immunogen is located within amino acids 80 - 130 of TPT1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
TPT1 antibody can be used for detection of TPT1 by Western blot at 0.5 - 1 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1303 - Human Brain Tissue Lysate
Predicted Molecular Weight:
Predicted: 19 kDa
Purification:
TPT1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
TPT1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
TPT1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
TPT1
Additional Names:
TPT1 Antibody: HRF, p02, p23, TCTP, Translationally-controlled tumor protein, Fortilin
Protein Accession Number:
NP_003286
Protein Gi Number:
4507669
Ncbi Gene Id Number:
7178
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TPT1 Antibody: TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium binding proteins. TPT1 is localized in the cytoplasm and widely expressed and serves as a transcriptional activator, calcium transporter, histamine inducer and antiapoptotic caspase 3 inhibitor. TPT1 is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. TPT1 plays a pivotal role in allergic diseases and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer's disease and Down syndrome.
Background Reference 1:
MacDonald SM, Rafnar T, Langdon J, et al. Molecular identification of an IgE-dependent histamine-releasing factor. Science 1995; 269:688-90.
Background Reference 2:
MacDonald SM. Human recombinant histamine-releasing factor. Int. Arch. Allergy Immunol. 1997; 113:187-9.
Background Reference 3:
Sanchez JC, Schaller D, Ravier F, et al. Translationally controlled tumor protein: a protein identified in several nontumoral cells including erythrocytes. Electrophoresis 1997; 18:150-5.
Background Reference 4:
Kuna P and Kaplan AP. Relationship of histamine-releasing factors and histamine-releasing inhibitory factors to chemokine group of cytokine. Allergy Asthma Proc. 1996; 17:5-11.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7193

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

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