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Western blot analysis in NCI-H460 cell line lysates (35ug/lane).
Western blot analysis in mouse liver tissue lysates (35ug/lane).
Western blot analysis in NCI-H460 cell line lysates (35ug/lane).

TRAF1 Antibody

CATALOG NUMBER: 57-370

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
This TRAF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human TRAF1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
46 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TRAF1
Additional Names:
TNF receptor-associated factor 1, Epstein-Barr virus-induced protein 6, TRAF1, EBI6
Protein Accession Number:
Q13077
Protein Gi Number:
6707734
Ncbi Gene Id Number:
7185
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene is a member of the TNFreceptor (TNFR) associated factor (TRAF) protein family. TRAFproteins associate with, and mediate the signal transduction fromvarious receptors of the TNFR superfamily. This protein and TRAF2form a heterodimeric complex, which is required forTNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. Theprotein complex formed by this protein and TRAF2 also interactswith inhibitor-of-apoptosis proteins (IAPs), and thus mediates theanti-apoptotic signals from TNF receptors. The expression of thisprotein can be induced by Epstein-Barr virus (EBV). EBV infectionmembrane protein 1 (LMP1) is found to interact with this and otherTRAF proteins; this interaction is thought to link LMP1-mediated Blymphocyte transformation to the signal transduction from TNFRfamily receptors. Three transcript variants encoding two differentisoforms have been found for this gene.
Background Reference 1:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 2:
Plant, D., et al. Ann. Rheum. Dis. 69(8):1548-1553(2010)
Background Reference 3:
Stahl, E.A., et al. Nat. Genet. 42(6):508-514(2010)
Background Reference 4:
Tan, R.J., et al. Ann. Rheum. Dis. 69(6):1029-1035(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-370

List Size:
400 ul

List Price:

$495.00

Datasheet
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