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TRAIL-R2 Antibody [HS201] (biotin)

CATALOG NUMBER: 36-130

Clonality:
Monoclonal
Tested Applications:
Flow, Functional Assays, ICC, IHC, IP
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Biotin
Specifications
Host Species:
Mouse
Species Reactivity:
Human
Immunogen:
Recombinant human TRAIL-R2 (DR5).
Conjugate:
Biotin
Tested Applications:
Flow, Functional Assays, ICC, IHC, IP
Application Note:
Functional Application: Inhibition (blocks TRAIL-R2 mediated killing if applied in solution). Immunohistochemistry: (paraffin sections, 15ug/ml).
Specificity:
Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, -R3 or -R4.
Purification:
>95% (SDS-PAGE)
Clonality:
Monoclonal
Isotype:
IgG1
physical-state:
Liquid
Buffer:
Liquid. In PBS containing 0.02% sodium azide.
Concentration:
0.5 mg/ml
Storage Conditions:
Stable for at least 1 year after receipt when stored at -20°C.
Ncbi Official Symbol:
TNFRSF10B
Additional Names:
TRAIL Receptor 2; DR5; KILLER; TNFRSF10B; CD262
Protein Accession Number:
2338419
Protein Gi Number:
AF012535
Ncbi Gene Id Number:
8795
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

36-130

List Size:
100 ug

List Price:

$577.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

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