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Western blot analysis of TREM1 in 293 cell lysate with TREM1 antibody at (A) 1 and (B) 2 μg/mL.
Western blot analysis of TREM1 in 293 cell lysate with TREM1 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

TREM1 Antibody

CATALOG NUMBER: 7185

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (71%)
Immunogen:
Rabbit polyclonal TREM1 antibody was raised against a 17 amino acid peptide near the amino terminus of human TREM1.
The immunogen is located within the first 50 amino acids of TREM1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
TREM1 antibody can be used for detection of TREM1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1210 - HEK293 Cell Lysate
Predicted Molecular Weight:
Predicted: 26 kDa
Purification:
TREM1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
TREM1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
TREM1 antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TREM1
Additional Names:
TREM1 Antibody: CD354, TREM-1, Triggering receptor expressed on myeloid cells 1, Triggering receptor expressed on monocytes 1
Protein Accession Number:
NP_061113
Protein Gi Number:
8924262
Ncbi Gene Id Number:
54210
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TREM1 Antibody: TREM1 (triggering receptor expressed on myeloid cells 1) is a receptor belonging to the Ig superfamily that amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. It is thought that TREM1 other related TREM proteins such as TREM2 act to modulate the inflammatory response. TREM1 has also been linked to inflammatory bowel disease resulting in enhanced production of TNF, IL-6, IL-8, and MCP-1.
Background Reference 1:
Bouchon A, Facchetti F, Weigand MA, et al. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 2001; 410:1103-7.
Background Reference 2:
Ford JW and McVicar DW. TREM and TREM-like receptors in inflammation and disease. Curr. Opin. Immunol. 2009; 21:38-46
Background Reference 3:
Schenk M, Bouchon A, Seibold F, et al. TREM-1-expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J. Clin. Invest. 2007; 117:3097-106.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7185

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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