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Western blot analysis of TRIP6 in A431 cell lysate with TRIP6 antibody at 1 μg/mL.
Immunocytochemistry of TRIP6 in HeLa cells with TRIP6 antibody at 10 μg/mL.
Immunofluorescence of TRIP6 in HeLa cells with TRIP6 antibody at 20 μg/mL.
Western blot analysis of TRIP6 in A431 cell lysate with TRIP6 antibody at 1 μg/mL.
Trial Size

TRIP6 Antibody

CATALOG NUMBER: 6001

Clonality:
Polyclonal
Tested Applications:
ELISA, ICC, IF, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (86%)
Immunogen:
TRIP6 antibody was raised against a 15 amino acid synthetic peptide near the center of human TRIP6.
The immunogen is located within amino acids 190 - 240 of TRIP6.
Conjugate:
Unconjugated
Tested Applications:
ELISA, ICC, IF, WB
Application Note:
TRIP6 antibody can be used for detection of TRIP6 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1202 - A431 Cell Lysate
Positive Control 2:
Cat. No. 17-001 - HeLa Cell Slide
Purification:
TRIP6 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
TRIP6 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
TRIP6 antibody can be stored at 4μC for three months and -20μC, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TRIP6
Additional Names:
TRIP6 Antibody: OIP1, OIP-1, ZRP-1, TRIP-6, TRIP6i2, OIP1, Thyroid receptor-interacting protein 6, Opa-interacting protein 1, TR-interacting protein 6
Protein Accession Number:
NP_003293
Protein Gi Number:
91208423
Ncbi Gene Id Number:
7205
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TRIP6 Antibody: TRIP6 (Thyroid receptor interacting protein 6) is a zyxin-related focal adhesion molecule involved in cell motility and antiapoptotic responses. TRIP6 is predominantly expressed in kidney, liver and lung. It has three LIM domains, a PDZ-binding motif, a Crk SH2-binding motif and/or other protein interacting domains. TRIP6 regulates NF-κB activation and interacts with RICK and TRAF2, proteins that are involved in TNF signaling. TRIP6 antagonizes Fas-induced apoptosis and promotes Fas-mediated cell migration in apoptosis-resistant glioma cells via Src-dependent phosphorylation of TRIP6 at Tyr-55.
Background Reference 1:
Murthy KK, Clark K, Fortin Y, et al. ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E. J. Biol. Chem.1999; 274:20679-87.
Background Reference 2:
Kassel O, Schneider S, Heilbock C, et al. A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB regulated promoters. Genes Dev.2004; 18:2518-2528.
Background Reference 3:
Lai YJ, Chen CS, Lin WJ, et al. c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration. Mol. Cell. Biol.2005; 25:5859-5868.
Background Reference 4:
Li L, Bin LH, Li F, et al. TRIP6 is a RIP2-associated common signaling component of multiple NF-kB activation pathways. J. Cell. Sci.2005; 118:555-563.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6001

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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