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Western blot analysis of lysed extracts from Rat and Mouse brain tissue using TrkA (Phospho-Ser791).
Immunofluorescence staining of methanol-fixed HeLa cells using TrkA (Phospho-Ser791).
Western blot analysis of lysed extracts from Rat and Mouse brain tissue using TrkA (Phospho-Ser791).

TrkA (phospho Ser791) Antibody

CATALOG NUMBER: 79-501

Clonality:
Polyclonal
Tested Applications:
IF, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
TrkA (Phospho-Ser791) antibody was raised against a peptide sequence around phosphorylation site of tyrosine791 (P-V-Y (p) -L-D) derived from Human TrkA.
Conjugate:
Unconjugated
Tested Applications:
IF, WB
Application Note:
Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Specificity:
This antibody detects endogenous level of TrkA only when phosphorylated at tyrosine 791.
Predicted Molecular Weight:
140 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Clonality:
Polyclonal
physical-state:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
NTRK1
Additional Names:
MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, MGF, SCF, High affinity nerve growth factor receptor precursor, NTRK1, Slow nerve growth factor receptor, TRK1 transforming tyrosine kinase protein
Protein Accession Number:
NP_001007793.1
Protein Gi Number:
56118210
Ncbi Gene Id Number:
4914
Background:
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC γ1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC γ1-dependent signaling pathway.
Background Reference 1:
Wiese S, et al. Proc Natl Acad Sci U S A. 2007 Oct 23; 104 (43): 17210-5. Valdez G, et al. Proc Natl Acad Sci U S A. 2007 Jul 24;104 (30): 12270-5Inoue K, et al. J Biol Chem. 2007 Aug 17;282 (33): 24175-84

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-501

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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