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Western blot analysis of Trophinin in rat liver tissue lysate with Trophinin antibody at 1 μg/ml.
Immunohistochemistry of TROPHININ in mouse liver tissue with TROPHININ antibody at 10 μg/ml.
Immunofluorescence of Trophinin in mouse liver tissue with Trophinin antibody at 20 μg/ml.<br><br>Red: Trophinin Antibody (8245) <br> Blue: DAPI staining
Western blot analysis of Trophinin in rat liver tissue lysate with Trophinin antibody at 1 μg/ml.
Trial Size

Trophinin Antibody

CATALOG NUMBER: 8245

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Trophinin antibody was raised against a 16 amino acid peptide near the amino terminus of human Trophinin.
The immunogen is located within amino acids 390 - 440 of Trophinin.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
Trophinin antibody can be used for detection of Trophinin by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry at 10 μg/ml.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Specificity:
Trophinin antibody is human, mouse and rat reactive. Multiple isoforms of Trophinin are known to exist.
Positive Control 1:
Cat. No. 1464 - Rat Liver Tissue Lysate
Predicted Molecular Weight:
Predicted: 78, 157 kDa
Observed: 94 kDa
Purification:
Trophinin antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Trophinin antibody is supplied in PBS containing ≤0.09% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
Trophinin antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
TRO
Additional Names:
TRO, MAGE-d3, MAGED3
Protein Accession Number:
NP_001034794
Protein Gi Number:
89276766
Ncbi Gene Id Number:
7216
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Trophinin, also known as TRO or MAGED3, is an apical cell adhesion molecule that is implicated in the initial attachment during the process of embryo implantation and functions by mediating cell adhesion between trophoblastic and endometrial epithelial cells (1,2). Trophinin is a membrane protein expressed in chorionic villi trophoblasts and in maternal endometrial epithelial cells in an implantation-dependent manner and interacts with Bystin and Tastin, facilitating cell adhesion and embryo implantation (3,4). The induction of Trophinin expression may be a useful method for improving implantation rates and can be a potential diagnostic factor and biomarker for human cancer (4,5).
Background Reference 1:
Fukuda MN, Sato T, Nakayama J, et al. Trophinin and tastin, a novel cell adhesion molecule complex with potential involvement in embryo implantation. Genes Dev. 1995; 9:1199-210.
Background Reference 2:
Ma L, Yin M, Wu X, et al. Expression of trophinin and bystin identifies distinct cell types in the germinal zones of adult rat brain. Eur. J. Neurosci. 2006; 23:2265-76.
Background Reference 3:
Tamura N, Sugihara K, Akama TO, et al. Trophinin-mediated cell adhesion induces apoptosis of human endometrial epithelial cells through PKC-d. Cell Cycle 2011; 10:135-43.
Background Reference 4:
Chen KY, Lee YC, Lai JM, et al. Identification of trophinin as an enhancer for cell invasion and a prognostic factor for early stage lung cancer. Eur. J. Cancer. 2007; 43:782-90.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

8245

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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