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TSG Recombinant Protein

CATALOG NUMBER: 40-205

Specifications
source-species:
E. coli
Species:
Human
source-species:
E. coli
Recombinant Protein Sequence:
MCNKALCASD VSKCLIQELC QCRPGEGNCS CCKECMLCLG ALWDECCDCV GMCNPRNYSD TPPTSKSTVE ELHEPIPSLF RALTEGDTQL NWNIVSFPVA EELSHHENLV SFLETVNQPH HQNVSVPSNN VHAPYSSDKE HMCTVVYFDD CMSIHQCKIS CESMGASKYR WFHNACCECI GPECIDYGSK TVKCMNCMF
Biological Activity:
Biological activity was determined by its ability to neutralize BMP - 6 induced alkaline phosphatase production by ATDC chondrogenic cells. The expected ED50 for this effect is < 2.0 μg/mL of TSG.
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
physical-state:
Lyophilized
Storage Conditions:
The lyophilized TSG recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted TSG is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing TSG recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Ncbi Official Symbol:
TWSG1
Additional Names:
TSG, TSG, PSEC0250, Twisted gastrulation protein homolog 1
Protein Accession Number:
NP_065699.1
Protein Gi Number:
10190664
Ncbi Gene Id Number:
57045
Background:
Twisted Gastrulation Protein (TSG) is a secreted BMP binding protein structurally related to the BMP antagonists Chordin and Noggin. TSG can inhibit BMP activity by binding directly to BMP proteins, and can act either as a BMP4 agonist or antagonist (depending on the specific biochemical environment) by binding to the BMP4/Chordin complex. Recombinant human TSG is a 199 amino acid 22.2 kDa protein containing the BMP/TGFβ binding portion of the full length TSG protein.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

40-205

List Size:
0.01 mg, 0.05 mg

List Price:

Price range: $199.00 through $305.00

Datasheet
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