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The purity of rh COMP was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
The purity of rh COMP was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.

TSP5 Recombinant Protein

CATALOG NUMBER: 96-196

Tested Applications:
WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Gln 21 - Ala 757
Fusion Tag:
His Tag
Tested Applications:
WB
Application Note:
This recombinant protein can be used for WB. For research use only.
Predicted Molecular Weight:
82 kDa
Purity:
>88% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
COMP
Additional Names:
COMP, TSP5, EDM1, EPD1, MED, PSACH, THBS5
Protein Accession Number:
AAI25093
Ncbi Gene Id Number:
1311
Background:
Cartilage oligomeric matrix protein (COMP) is also known as Thrombospondin-5 (TSP5), EDM1, EPD1, MED, PSACH, THBS5, which belongs to the thrombospondin family. COMP / TSP5 contains 4 EGF-like domains, 1 TSP C-terminal (TSPC) domain, 8 TSP type-3 repeats. Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. COMP may play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. COMP can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Thrombospondin-5 could play a role in the pathogenesis of osteoarthritis. COMP is a marker of cartilage turnover.
Background Reference 1:
Chen F.-H., et al., 2006, J. Biol. Chem. 280:32655-32661.
Background Reference 2:
Koelling S., et al., 2006, Arthritis Res. Ther. 8:R56-R56.
Background Reference 3:
Gagarina V., et al., 2008, J. Biol. Chem. 283:648-659.
Background Reference 4:
Petersen, G., et al., 2009, Osteoarthritis and Cartilage 18 (1): 34–40.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-196

List Size:
0.1 mg

List Price:

$463.00

Datasheet
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