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TWEAK Recombinant Protein

CATALOG NUMBER: 40-298

Specifications
source-species:
E. coli
Species:
Human
source-species:
E. coli
Recombinant Protein Sequence:
MKGRKTRARR AIAAHYEVHP RPGQDGAQAG VDGTVSGWEE ARINSSSPLR YNRQIGEFIV TRAGLYYLYC QVHFDEGKAV YLKLDLLVDG VLALRCLEEF SATAASSLGP QLRLCQVSGL LALRPGSSLR IRTLPWAHLK AAPFLTYFGL FQVH
Biological Activity:
Assay 1: The ED50 was determined by the dose - dependent stimulation of IL - 8 production by Human PBMC is less than 10 ng/mL.

Assay 2: TWEAK weakly induces the death of HT29 cells when cultured in the presence of IFN - γ. The ED50 for this effect is between 30 - 45 ng/mL.
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
physical-state:
Lyophilized
Storage Conditions:
The lyophilized TWEAK recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted TWEAK is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing TWEAK recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Ncbi Official Symbol:
TNFSF12
Additional Names:
APO3L, DR3LG, TWEAK, APO3L, UNQ181/PRO207, Tumor necrosis factor ligand superfamily member 12, APO3 ligand
Protein Accession Number:
NP_003800.1
Protein Gi Number:
4507597
Ncbi Gene Id Number:
8742
Background:
TWEAK belongs to the TNF family of ligands and signals through TWEAKR also known as TNFRSF12A. TWEAK is expressed in a variety of tissues, including the adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes. TWEAK has the ability to induce NFkB activation and chemokine secretion, and to exert an apoptotic activity in certain cells, such as HT-29 human adenocarcinoma cells when cultured in the presence of IFN-γ. TWEAK also promotes proliferation and migration of endothelial cells. Recombinant human TWEAK is a soluble 17.0 kDa polypeptide (154 amino acid residues) comprising the TNF homologous region of TWEAK and is generated by proteolytic processing of the full length membrane anchored TWEAK protein.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

40-298

List Size:
0.005 mg, 0.025 mg

List Price:

Price range: $199.00 through $305.00

Datasheet
Shipping Info

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