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Western blot analysis of TYK2 in human small intestine tissue lysate with TYK2 antibody at (A) 1 and (B) 2 μg/mL
Immunofluorescence of TYK2 in A549 cells with TYK2 Antibody at 20 μg/ml.
Western blot analysis of TYK2 in human small intestine tissue lysate with TYK2 antibody at (A) 1 and (B) 2 μg/mL
Trial Size

TYK2 Antibody

CATALOG NUMBER: 7177

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Rabbit polyclonal TYK2 antibody was raised against a 17 amino acid peptide near the amino terminus of human TYK2.
The immunogen is located within amino acids 90 - 140 of TYK2.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, WB
Application Note:
TYK2 antibody can be used for detection of TYK2 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity:
At least three isoforms of TYK2 are known to exist; this antibody only detects the two longest isoforms.
Positive Control 1:
Cat. No. 1308 - Human Small Intestine Tissue Lysate
Predicted Molecular Weight:
Predicted: 131 kDa
Purification:
TYK2 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
TYK2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
TYK2 antibody can be stored at 4°C, stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TYK2
Additional Names:
TYK2 Antibody: JTK1, Non-receptor tyrosine-protein kinase TYK2
Protein Accession Number:
NP_003322
Protein Gi Number:
187608615
Ncbi Gene Id Number:
7297
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TYK2 Antibody: TYK2 is a member of the Janus kinases (JAKs) protein families. TYK2 associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits and is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Background Reference 1:
Strobl B, Stoiber D, Sexl V, et al. Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunity. Front. Biosci. 2011; 17:3214-32.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7177

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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