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Western blot of 10 ug of rat caudate lysate showing specific immunolabeling of the ~60k TH protein.
Western blot of 10 ug of rat caudate lysate showing specific immunolabeling of the ~60k TH protein.

Tyrosine Hydroxylase Antibody

CATALOG NUMBER: 50-262

Clonality:
Polyclonal
Tested Applications:
IF, IHC, WB
Host Species:
Rabbit
Species Reactivity:
Mammal
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Mammal
Immunogen:
SDS-denatured rat tyrosine hydroxylase, purified from pheochromocytoma.
Conjugate:
Unconjugated
Tested Applications:
IF, IHC, WB
Specificity:
Specific for the ~60k tyrosine hydroxylase protein.
Predicted Molecular Weight:
60
Purification:
Affinity Purified
Clonality:
Polyclonal
physical-state:
Liquid
Concentration:
batch dependent
Storage Conditions:
Tyrosine Hydroxylase antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
Ncbi Official Symbol:
Th
Protein Accession Number:
P04177
Protein Gi Number:
136577
Ncbi Gene Id Number:
25085
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001; Dunkley et al., 2004).
Background Reference 1:
Dunkley PR, Bobrovskaya L, Graham ME, Von Nagy-Felsobuki EI, Dickson PW (2004) Tyrosine hydroxylase phosphorylation: regulation and consequences. J Neurochem 91:1025-1043.
Background Reference 2:
Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, Haycock JW (2001) Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology 24:561-567.
Background Reference 3:
Salvatore MF, Waymire JC, Haycock JW (2001) Depolarization-stimulated catecholamine biosynthesis: involvement of protein kinases and tyrosine hydroxylase phosphorylation sites in situ. J Neurochem 79:349-360.

FOR RESEARCH USE ONLY

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Disclaimer:
This product is for research use only.

CATALOG NUMBER:

50-262

List Size:
0.1 mL

List Price:

$540.00

Datasheet
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