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Western blot analysis in CEM cell line lysates (35ug/lane).
UBA7 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human esophagus carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in CEM cell line lysates (35ug/lane).

UBA7 Antibody

CATALOG NUMBER: 57-551

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This UBA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-268 amino acids from the N-terminal region of human UBA7.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
112 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
UBA7
Additional Names:
Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-activating enzyme 7, D8, Ubiquitin-activating enzyme E1 homolog, UBA7, UBE1L, UBE2
Protein Accession Number:
P41226
Protein Gi Number:
215273977
Ncbi Gene Id Number:
7318
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The modification of proteins with ubiquitin is animportant cellular mechanism for targeting abnormal or short-livedproteins for degradation. Ubiquitination involves at least threeclasses of enzymes: ubiquitin-activating enzymes, or E1s,ubiquitin-conjugating enzymes, or E2s, and ubiquitin-proteinligases, or E3s. This gene encodes a member of the E1ubiquitin-activating enzyme family. The encoded enzyme is aretinoid target that triggers promyelocytic leukemia (PML)/retinoicacid receptor alpha (RARalpha) degradation and apoptosis in acutepromyelocytic leukemia, where it is involved in the conjugation ofthe ubiquitin-like interferon-stimulated gene 15 protein. [providedby RefSeq].
Background Reference 1:
Fransen, K., et al. Hum. Mol. Genet. 19(17):3482-3488(2010)
Background Reference 2:
Morgan, A.R., et al. Hum. Immunol. 71(6):602-609(2010)
Background Reference 3:
Feng, Q., et al. Mol. Cancer Ther. 7(12):3780-3788(2008)
Background Reference 4:
Durfee, L.A., et al. J. Biol. Chem. 283(35):23895-23902(2008)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-551

List Size:
400 ul

List Price:

$495.00

Datasheet
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