UGDH Antibody

CATALOG NUMBER: 56-538

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This UGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 465-494 amino acids from the C-terminal region of human UGDH.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
55 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
UGDH
Additional Names:
UDP-glucose 6-dehydrogenase, UDP-Glc dehydrogenase, UDP-GlcDH, UDPGDH, UGDH
Protein Accession Number:
O60701
Ncbi Gene Id Number:
7358
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene converts UDP-glucose toUDP-glucuronate and thereby participates in the biosynthesis ofglycosaminoglycans such as hyaluronan, chondroitin sulfate, andheparan sulfate. These glycosylated compounds are common componentsof the extracellular matrix and likely play roles in signaltransduction, cell migration, and cancer growth and metastasis. Theexpression of this gene is up-regulated by transforming growthfactor beta and down-regulated by hypoxia. Alternative splicingresults in multiple transcript variants.
Background Reference 1:
Wang, T.P., et al. Exp. Cell Res. 316(17):2893-2902(2010)
Background Reference 2:
Hodgkinson, C.A., et al. Proc. Natl. Acad. Sci. U.S.A. 107(19):8695-8700(2010)
Background Reference 3:
Huang, D., et al. Int. J. Cancer 126(2):315-327(2010)
Background Reference 4:
Lee, H.S., et al. Arch. Biochem. Biophys. 486(1):35-43(2009)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

56-538

List Size:
400 ul

List Price:

$495.00

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