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Western Blot at 1:1000 dilution Lane 1: HT-1080 whole cell lysate Lane 2: U-251 MG whole cell lysate Lysates/proteins at 20 ug per lane.
Western blot analysis of ULBP2 using rabbit polyclonal ULBP2 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ULBP2 gene.
Western Blot at 1:1000 dilution Lane 1: HT-1080 whole cell lysate Lane 2: U-251 MG whole cell lysate Lysates/proteins at 20 ug per lane.

ULBP2 Antibody

CATALOG NUMBER: 58-936

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This ULBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-116 amino acids from the Central region of human ULBP2.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
27 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
ULBP2
Additional Names:
NKG2D ligand 2, N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2, N2DL2, RAET1H
Protein Accession Number:
Q9BZM5
Ncbi Gene Id Number:
80328
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
Background Reference 1:
McGilvray, R.W., et al. Int. J. Cancer 127(6):1412-1420(2010)
Background Reference 2:
Nuckel, H., et al. Leukemia 24(6):1152-1159(2010)
Background Reference 3:
Antoun, A., et al. Hum. Immunol. 71(6):610-620(2010)
Background Reference 4:
Davila, S., et al. Genes Immun. 11(3):232-238(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-936

List Size:
400 ul

List Price:

$495.00

Datasheet
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