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Western blot analysis in MCF-7 cell line lysates (35ug/lane).
Flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Western blot analysis in MCF-7 cell line lysates (35ug/lane).

UPF2 Antibody

CATALOG NUMBER: 55-346

Clonality:
Polyclonal
Tested Applications:
Flow, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This UPF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 630-656 amino acids from the Central region of human UPF2.
Conjugate:
Unconjugated
Tested Applications:
Flow, WB
Application Note:
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
Predicted Molecular Weight:
148 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
UPF2
Additional Names:
Regulator of nonsense transcripts 2, Nonsense mRNA reducing factor 2, Up-frameshift suppressor 2 homolog, hUpf2, UPF2, KIAA1408, RENT2
Protein Accession Number:
Q9HAU5
Protein Gi Number:
60390647
Ncbi Gene Id Number:
26019
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
UPF2 is a protein that is part of apost-splicing multiprotein complex involved in both mRNA nuclearexport and mRNA surveillance. mRNA surveillance detects exportedmRNAs with truncated open reading frames and initiatesnonsense-mediated mRNA decay (NMD). When translation ends upstreamfrom the last exon-exon junction, this triggers NMD to degrademRNAs containing premature stop codons. This protein is located inthe perinuclear area. It interacts with translation release factorsand the proteins that are functional homologs of yeast Upf1p andUpf3p.
Background Reference 1:
Clerici, M., et al. EMBO J. 28(15):2293-2306(2009)
Background Reference 2:
Cronin, S., et al. Eur. J. Hum. Genet. 17(2):213-218(2009)
Background Reference 3:
Woeller, C.F., et al. EMBO Rep. 9(5):446-451(2008)
Background Reference 4:
Chamieh, H., et al. Nat. Struct. Mol. Biol. 15(1):85-93(2008)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

55-346

List Size:
400 ul

List Price:

$495.00

Datasheet
Shipping Info

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