USP14 Antibody

CATALOG NUMBER: 60-770

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Bovine
Immunogen:
This USP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-383 amino acids from the C-terminal region of human USP14.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
56 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
USP14
Additional Names:
Ubiquitin carboxyl-terminal hydrolase 14, Deubiquitinating enzyme 14, Ubiquitin thioesterase 14, Ubiquitin-specific-processing protease 14, USP14, TGT
Protein Accession Number:
P54578
Protein Gi Number:
1729927
Ncbi Gene Id Number:
9097
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a member of the ubiquitin-specificprocessing (UBP) family of proteases that is a deubiquitinatingenzyme (DUB) with His and Cys domains. This protein is located inthe cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fusedprecursors and ubiquitinylated proteins. Mice with a mutation thatresults in reduced expression of the ortholog of this protein areretarded for growth, develop severe tremors by 2 to 3 weeks of agefollowed by hindlimb paralysis and death by 6 to 10 weeks of age.Alternate transcriptional splice variants, encoding differentisoforms, have been characterized.
Background Reference 1:
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Background Reference 2:
Chen, P.C., et al. J. Neurosci. 29(35):10909-10919(2009)
Background Reference 3:
Mines, M.A., et al. J. Biol. Chem. 284(9):5742-5752(2009)
Background Reference 4:
Nagai, A., et al. Biochem. Biophys. Res. Commun. 379(4):995-1000(2009)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-770

List Size:
400 ul

List Price:

$495.00

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