VASP Antibody

CATALOG NUMBER: 57-408

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This VASP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-296 amino acids from the C-terminal region of human VASP.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:2000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
40 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
VASP
Additional Names:
Vasodilator-stimulated phosphoprotein, VASP, VASP
Protein Accession Number:
P50552
Protein Gi Number:
1718079
Ncbi Gene Id Number:
7408
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Vasodilator-stimulated phosphoprotein (VASP) is a memberof the Ena-VASP protein family. Ena-VASP family members contain anEHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/Emotifs and targets Ena-VASP proteins to focal adhesions. In themid-region of the protein, family members have a proline-richdomain that binds SH3 and WW domain-containing proteins. TheirC-terminal EVH2 domain mediates tetramerization and binds both Gand F actin. VASP is associated with filamentous actin formationand likely plays a widespread role in cell adhesion and motility.VASP may also be involved in the intracellular signaling pathwaysthat regulate integrin-extracellular matrix interactions. VASP isregulated by the cyclic nucleotide-dependent kinases PKA and PKG.
Background Reference 1:
Barragan, P., et al. Thromb. Haemost. 104(2):410-411(2010)
Background Reference 2:
Dittrich, M., et al. Arterioscler. Thromb. Vasc. Biol. 30(4):843-850(2010)
Background Reference 3:
Gan, L., et al. Mol. Immunol. 47(6):1278-1282(2010)
Background Reference 4:
Osmancik, P., et al. Catheter Cardiovasc Interv 75(2):158-166(2010)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-408

List Size:
400 ul

List Price:

$519.00

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