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Western blot analysis in CEM cell line lysates (35ug/lane).
Western blot analysis in CEM cell line lysates (35ug/lane).

VAV1 Antibody

CATALOG NUMBER: 57-309

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This VAV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 437-466 amino acids from the Central region of human VAV1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
98 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
VAV1
Additional Names:
Proto-oncogene vav, VAV1, VAV
Protein Accession Number:
P15498
Protein Gi Number:
13124807
Ncbi Gene Id Number:
7409
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this proto-oncogene is a member ofthe Dbl family of guanine nucleotide exchange factors (GEF) for theRho family of GTP binding proteins. The protein is important inhematopoiesis, playing a role in T-cell and B-cell development andactivation. This particular GEF has been identified as the specificbinding partner of Nef proteins from HIV-1. Coexpression andbinding of these partners initiates profound morphological changes,cytoskeletal rearrangements and the JNK/SAPK signaling cascade,leading to increased levels of viral transcription and replication.
Background Reference 1:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 2:
Hollmann, A., et al. Hematol Oncol 28(3):142-150(2010)
Background Reference 3:
Barda-Saad, M., et al. EMBO J. 29(14):2315-2328(2010)
Background Reference 4:
Davila, S., et al. Genes Immun. 11(3):232-238(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-309

List Size:
400 ul

List Price:

$495.00

Datasheet
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