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Mouse VEGF R1, Mouse IgG2a Fc Tag, low endotoxin on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 85%.
Immobilized Human VEGF165, Tag Free at 2 ug/mL (100 uL/well) can bind Mouse VEGF R1, Mouse IgG2a Fc Tag, low endotoxin with a linear range of 2-31 ng/mL (QC tested).
Immobilized Human VEGF-B, His Tag at 2 ug/mL (100 uL/well) can bind Mouse VEGF R1, Mouse IgG2a Fc Tag, low endotoxin with a linear range of 8-63 ng/mL (Routinely tested).
Mouse VEGF R1, Mouse IgG2a Fc Tag, low endotoxin on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 85%.

VEGF R1 / Flt-1 Recombinant Protein

CATALOG NUMBER: 11-520

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Mouse
source-species:
HEK293 cells
Recombinant Protein Sequence:
Tyr 23 - Glu 759
Fusion Tag:
Mouse IgG Fc Tag
Tested Applications:
ELISA, WB
Application Note:
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 109.8 kDa. The protein migrates as 140 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Predicted Molecular Weight:
109.8 kDa
Purity:
>85% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
50 mM Tris, 100 mM Glycine, pH7.5
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
Flt1
Additional Names:
FLT,VEGFR1,FLT1
Protein Accession Number:
NP_034358.2
Ncbi Gene Id Number:
14254
Background:
Vascular endothelial growth factor receptor 1 (VEGFR1) is also known as Fms-like tyrosine kinase 1 (FLT-1), Tyrosine-protein kinase receptor FLT, is a single-pass type I membrane protein and secreted protein which belongs to the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR1 is detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues and specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. VEGFR1 acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR1 may play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. VEGFR1 can promote endothelial cell proliferation, survival and angiogenesis in adulthood.
Background Reference 1:
Shibuya M., et al., 1990, Oncogene 5:519-524.
Background Reference 2:
Kendall R.L., et al., 1993, Proc. Natl. Acad. Sci. U.S.A. 90:10705-10709.
Background Reference 3:
Seetharam L., et al., 1995, Oncogene 10:135-147.
Background Reference 4:
Barleon B., et al., 1996, Blood 87:3336-3343.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-520

List Size:
0.1 mg

List Price:

$515.00

Datasheet
Shipping Info

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