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Rhesus macaque VEGF R2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 97%.
Rhesus macaque VEGF R2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 97%.

VEGF R2 Recombinant Protein

CATALOG NUMBER: 97-070

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Rhesus monkey
source-species:
HEK293 cells
Recombinant Protein Sequence:
Ala 20 - Glu 764
Fusion Tag:
His Tag
Tested Applications:
ELISA, WB
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Predicted Molecular Weight:
85.2 kDa
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human VEGF165 at 2 ug/mL (100 uL/well) can bind Rhesus macaque VEGF R2, His Tag with a linear range of 4-60 ng/mL.
Purity:
>97% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
VEGF R2
Additional Names:
KDR,CD309,FLK1,VEGFR,VEGFR2
Protein Accession Number:
F7E313
Ncbi Gene Id Number:
698293
Background:
Kinase insert domain receptor (KDR) is also known as CD309, FLK1, VEGFR, VEGFR2, and is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain. VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF.The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo). In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Background Reference 1:
Holmes K,et al., 2007, Cell Signal. 19 (10): 2003–2012.
Background Reference 2:
Stuttfeld E, et al., 2009, IUBMB Life 61 (9): 915–22.
Background Reference 3:
Fujita, N, et al., 2008, Biochemical and biophysical research communications 372 (2): 367–372.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

97-070

List Size:
0.1 mg

List Price:

$515.00

Datasheet
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