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Western blot analysis of VENTX in mouse brain tissue lysate with VENTX antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of VENTX in rat brain tissue with VENTX antibody at 5 μg/mL.
Immunofluorescence of VENTX in rat brain tissue with VENTX antibody at 20 μg/mL.
Western blot analysis of VENTX in mouse brain tissue lysate with VENTX antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

VENTX Antibody

CATALOG NUMBER: 5863

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (92%), Chicken: (92%)
Immunogen:
VENTX antibody was raised against a 16 amino acid synthetic peptide near the center of human VENTX.
The immunogen is located within amino acids 120 - 170 of VENTX.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
VENTX antibody can be used for detection of VENTX by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1403 - Mouse Brain Tissue Lysate
Purification:
VENTX Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
VENTX Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
VENTX antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
VENTX
Additional Names:
VENTX Antibody: NA88A, HPX42B, VENTX2, Homeobox protein VENTX, VENT homeobox homolog
Protein Accession Number:
NP_055283
Protein Gi Number:
7657180
Ncbi Gene Id Number:
27287
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
VENTX Antibody: Lymphoid-enhancing factor/T-cell factors (LEF1/TCF) are a high-mobility group of transcriptional factors that play essential roles in cell fate determination during early embryogenesis and ontogenesis. VENTX is a member of the Vent family of homeodomain proteins. It is a novel LEF/TCF-associated transcriptional modulator. VENTX is predominately expressed in hematopoietic cells. VENTX may function as a transcriptional repressor and be involved in mesodermal patterning and hemapoietic stem cell maintenance, and has been suggested to have a potential role in the hematopoietic malignancies.
Background Reference 1:
Reya T and Clevers H. Wnt signalling in stem cells and cancer. Nature2005; 434:843-50.
Background Reference 2:
Moretti PA, Davidson AJ, Baker E, et al. Molecular cloning of a human Vent-like homeobox gene. Genomics2001; 76:21-9.
Background Reference 3:
Gao H, Le Y, Wu X, et al. VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor. Cancer Res.2010; 70:202-11.
Background Reference 4:
Shtutman M, Zhurinsky J, Simcha I, et al. The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway. Proc. Natl. Acad. Sci. USA1999; 96:5522-7.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

5863

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

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